Novel Technologies to Accelerate TPD Discovery Workshop Day
Monday, October 28 2024
Workshop A - 8.30am
Intergrating Structural Dynamics
Studies into Drug Discovery
Attend this workshop to:
- Overview of methods for observing ternary complex formation and their value for enabling SAR
- Focus on the unique advantages and challenges of cryo-EM and single particle analysis for leveraging conformational dynamics, specifically in the context of E3 ligases relevant to TP
- Discuss in depth time-resolved cryo-EM and its applications to merging quantitative biochemistry and structural biology for drug discovery
- Use high-purity FRET-active E2~Ub conjugates for monitoring degrader-mediated protein ubiquitylation in single-step FRET assays
Download the Full Event Guide for full details
Radoslav Enchev, Group Leader, The Francis Crick Institute
Dmitri Ivanov, Associate Professor, UT Health San Antonio
10:30am: Morning Break & Networking
Workshop B - 11.30am
Workshop C - 1.30pm