James Papatzimas

Company: Novartis

Job title: Principal Scientist

Seminars:

Gluing the Pieces Together, to Break it All Down: Harnessing Novel E3 Ligases for Molecular Glue Degraders 12:00 pm

The TPD field currently lacks rational chemical design principles for converting protein-targeting ligands into molecular glues Using known protein binders, we sought to identify transposable motifs which would convert these ligands into protein degraders RNF126, a previously unliganded RING E3 ligase, was determined to be an amenable ligase mediating a multitude of neo-substrate recognition events,…Read more

day: Bootcamp Day