Discovering & Characterizing Latent E3 Ligase Protein-Protein Interactions Against 150 Therapeutic Targets

Time: 9:00 am
day: Focus Day


  • Over 100 protein-protein interactions were identified between therapeutically relevant targets and a diverse set of ligases
  • A subset of these interactions was further characterized using site-directed mutagenesis to define the interface and explore the ability to modulate the interaction
  • These protein-protein interactions were used to prioritize small molecule discovery campaigns aimed at identifying molecular glues