Ryan Kerrigan

Company: Novartis

Job title: Principal Scientist II

Seminars:

Discovery & Optimization of First-in-Class Molecular Glue Degraders of the WIZ Transcription Factor for Fetal Hemoglobin Induction to Treat Sickle Cell Disease 4:00 pm

A phenotypic screen identified inducers of fetal hemoglobin to treat SCD Subsequent target elucidation identified CRBN dependent degradation of the transcription factor WIZ as driver of HbF induction Med chem optimization resulted in molecules with improved WIZ degradation selectivity and in vivo PK/PD and efficacy and candidates for developmentRead more

day: Focus Day