Gary Kleiger

Company: University of Las Vegas Nevada

Job title: Chair & Professor

Seminars:

Robust Cullin-RING Ligases Employ Geometrically Optimized Catalytic Partners for Substrate Targeting 4:00 pm

Cullin-RING ligases collaborate with multiple distinct E2s and the ARIH1 ubiquitin ligase to efficiently target thousands of protein substrate for ubiquitylation What in vitro assays demonstrate high predictive value towards degrader drug efficacy? How can this be optimized? Does in vitro ubiquitin ligase efficiency correlate with cellular neo-substrate degradation?Read more

day: Focus Day