Alessio Ciulli
Company: University of Dundee
Job title: Founder, Director & Professor - Chemical & Structural Biology
Seminars:
Honorary Opening Remarks 8:15 am
day: Day One AM
New Twists in Mechanisms & Rational Design of Protein Degraders 3:00 pm
Protein degraders (PROTACs, molecular glues) recruit a target protein to a ubiquitin E3 ligase, leading to the ubiquitination and subsequent proteasomal degradation of the target protein Degraders work via formation of a ternary complex target: degrader: ligase. Pioneering structural and biophysical studies have revealed molecular insights of degrader mechanism of action, and ushered their rational…Read more
day: Research Day
Panel Discussion: Looking Ahead: The Next Generation of Induced-Proximity-Based Therapeutic Discovery 1:30 pm
Moderator: Ian Churcher, Consultant, Janus Drug Discovery Where is TPD field going next? What are the biggest unsolved challenges and how might they be addressed? Which induced-proximity modalities have the most potential to match success of PROTACs?Read more
day: Research Day