Structure & Regulation of the Proteasome
Time: 9:30 am
day: Bootcamp Day
Details:
- The proteasome degrades ubiquitinated proteins by unfolding them and translocating them into a proteolytic chamber
- The proteasome is regulated by numerous cofactors, among them substrate delivery factors, inhibitors, deubiquitinating enzymes, protein kinases, ubiquitin ligases, and assembly chaperones
- Whether a ubiquitinated protein is a good proteasome substrate depends on multiple features, a major one being the presence of an “initiation element” that is is critical for effective unfolding
