Structural, Biochemical, Biophysical, & Computational Characterization of KT-474
Time: 3:30 pm
day: Day Two PM
Details:
- Heterobifunctional degrader KT-474 induces ternary complex formation, ubiquitination, and degradation of IRAK4
- Ternary complex structure shows novel protein-protein interactions important for ternary complex formation and stability
- Structural explanations for cooperativity and selectivity will be discussed
