Robust Cullin-RING Ligases Employ Geometrically Optimized Catalytic Partners for Substrate Targeting
Time: 3:30 pm
day: Focus Day
Details:
- Cullin-RING ligases collaborate with multiple distinct E2s and the ARIH1 ubiquitin ligase to efficiently target thousands of protein substrate for ubiquitylation
- What in vitro assays demonstrate high predictive value towards degrader drug efficacy? How can this be optimized?
- Does in vitro ubiquitin ligase efficiency correlate with cellular neo-substrate degradation?
