Optimizing in vitro ADME assays to Deliver Orally Bioavailable PROTACs & Innovation for Degrader Safety Assessments
Time: 11:30 am
day: Workshop Day
Details:
A significant challenge with oral bioavailability for large
and complex molecules like PROTACs, lies in their
propensity to experience poor intestinal absorption.
Factors such as low membrane permeability, instability
within the intestinal environment, and susceptibility to
enzymatic degradation, all can hinder their ability to be
orally bioavailable.
Attend this workshop to:
• How useful are ADME properties for design and
optimization of oral PROTACs?
• Opportunities of different analytical and in silico
tools to advance drug design
• Identify and resolve the challenges within in
vitro ADME assays in drug discovery (DDI, PPB,
Metabolic stability etc)