New Twists in Mechanisms & Rational Design of Protein Degraders
Time: 3:00 pm
day: Research Day
Details:
- Protein degraders (PROTACs, molecular glues) recruit a target protein to a ubiquitin E3 ligase, leading to the ubiquitination and subsequent proteasomal degradation of the target protein
- Degraders work via formation of a ternary complex target: degrader: ligase. Pioneering structural and biophysical studies have revealed molecular insights of degrader mechanism of action, and ushered their rational drug design
- This talk will highlight new twists in mechanisms (e.g. intramolecular bivalent glues); new approaches to degrader design (e.g. ternary complex-templated dynamic combinatorial chemistry); and new enabling tools to speed-up research in the community (e.g. CRBN-Midi and BromoTag)
