MicDrop – Phenotypic DEL Screen in Droplets for TPD
Time: 9:30 am
day: Focus Day
Details:
- Introduction to the concept of directed serendipity, a small-molecule equivalent of directed evolution enabled by DNA-encoded molecular glue library
- Overview of MicDrop, a phenotypic DEL platform enabled by droplet microfluidics and DNA-encoded one-bead one-compound library technology
- Walk-through of POI degradation screen data demonstrating the robustness of the platform with bead replicates and discovery of new glue degrader hits
