Harnessing Protein Degradation to Drug the Undruggable: The History & Promise of Targeted Protein Degradation
Time: 9:00 am
day: Bootcamp Day
Details:
- The field of targeted protein degradation has rapidly expanded to offer the potential to drug targets that were previously considered undruggable
- PROTACs, MoDEs, and molecular glues have led the way into clinical trials and have shown promise for durable, effective therapeutics in cancer and other indications
- Multiple new targeted protein degradation modalities have been developed in the preclinical space that may allow targeting signaling pathways, cell types and tissues that were previously thought to be difficult to drug
