Gluing the Pieces Together, to Break it All Down: Harnessing Novel E3 Ligases for Molecular Glue Degraders
Time: 12:00 pm
day: Bootcamp Day
Details:
- The TPD field currently lacks rational chemical design principles for converting protein-targeting ligands into molecular glues
- Using known protein binders, we sought to identify transposable motifs which would convert these ligands into protein degraders
- RNF126, a previously unliganded RING E3 ligase, was determined to be an amenable ligase mediating a multitude of neo-substrate recognition events, leading to the discovery that it could be harnessed in a protein complex and act as an effective ubiquitinating and degrading chaperone
