Enabling Insights into Molecular Glue MoA Toward Design of Potent & Selective CK1a Degraders
Time: 9:30 am
day: Day Two AM
Details:
- Understanding neosubstrate selectivity through degradation and ternary complex profiling of CRBN molecular glues
- Development of a potent CK1a-selective degrader guided by cellular degradation and ternary complex studies
- Correlating specific target degradation with cellular outcomes
