Discovery & Targeting of an hRpn13 Product by PROTACs & Degraders
Time: 3:30 pm
day: Research Day
Details:
- The structure of hRpn13 with a small molecule binder was used to generate an hRpn13 PROTAC
- An hRpn13 PROTAC discovered hRpn13Pru which is generated by proteasomes with cell-type dependency
- A class of hRpn13Pru degraders was developed for preclinical application
