Discovery of novel proximity-inducing compounds using DEL screening
Time: 11:00 am
day: Focus Day
Details:
- DNA-encoded chemical libraries (DECL) containing >100 billion compounds with a high diversity of chemical structures enable discovery of novel binders that induce protein – protein interactions (i.e. PROTACs and molecular glues)
- Informed DECL screening strategies and workflows significantly impact discovery of PROTAC and molecular glues compounds
- Multiple independent projects yielded confirmed PROTACs and molecular glues discovered from DECL screens highlighting the value of DECL screening for hit discovery in the TPD field.
