ASGPR vs M6PR: Common & Orthogonal Applications for Extracellular Protein Degradation
Time: 3:30 pm
day: Bootcamp Day
Details:
- Review of two endocytotic cell surface receptors, ASGPR and M6PR, and their uses for degrading soluble circulating and membrane proteins
- Novel proprietary ligands for ASGPR and M6PR as backbones for ATAC (ASGPR Targeting Chimeras) and MTAC (M6PR Targeting Chimeras) degraders
- In vitro and in vivo protein degradation studies comparing ATACs vs MTACs and therapeutic implications
