A Novel Approach to Targeted Protein Stabilization via E3 Ligase Inhibition
Time: 12:00 pm
day: Post-Conference Focus Day
Details:
- E3 ligase inhibition to stabilize proteins otherwise degraded in disease is an untapped therapeutic modality
- Introducing a novel platform for identification of direct inhibitors of E3 ligases and novel E3 ligases
- Selective and potent small molecule inhibitors of E3 ligases have been identified that stabilize tumour suppressor proteins and induce cell death in target tumour cell populations
