8:50 am Chair’s Opening Remarks
Keynote Plenary Session Highlighting Key Discoveries of Bifunctional Degraders to New Targets
9:00 am Novel Small Molecule Bifunctional Degraders of SOS1 For Inhibition of Pan-KRAS Mutant Cancers
Synopsis
• Kirsten rat sarcoma (KRAS) is the most frequently mutated oncogene in human cancer. The guanine nucleotide exchange factor, son of sevenless
homolog 1 (SOS1), exchanges GDP for GTP in KRAS, inducing activation of KRAS
• Biotheryx’s PRODEGY platform has enabled the discovery of bifunctional molecules that demonstrate rapid, deep, proteasome-dependent
degradation of SOS1
• These novel SOS1 bifunctional degraders are potent inhibitors of KRAS mutant cell lines, including G12V, G12C, and G13D mutant forms, and are a
promising class of novel degraders with potential to be a first-in-class therapy for cancer patients
For more information on this session, please download the full event guide.
9:30 am PROTAC Development & Optimization to Target an Endoplasmic Reticulum Membrane Protein
Synopsis
• Discovery of a novel target class for PROTACs which is localized to the endoplasmic reticulum
• Novel PROTAC target disclosure
• PROTAC Prodrug
• PROTAC optimization, including structures
For more information on this session, please download the full event guide.
10:00 am Panel Discussion: TPD in Oncology & Beyond
Synopsis
• Which targets are the right ones to degrade?
• Which are the best modalities to pursue (heterobifunctionals, glues) based on target expression, compound distribution, desired PD response?
• How do we degrade targets beyond what PROTACs/glues can do?
• What diseases could degraders treat in the future?
For more information on this session, please download the full event guide.
Tech Slam: Hear An Exclusive Update of the Latest Technology Available to You to Support Your Efforts in 2022 & Beyond
10:30 am Mass Photometry – Weighing Molecules with Light
Synopsis
For more information on this session, please download the full event guide.
10:40 am Deep Proteomic Screening for Systematic Discovery of Degrader Targets
Synopsis
For more information on this session, please download the full event guide.
10:50 am Details to Be Revealed
Synopsis
11:00 am Morning Refreshments
12:30 pm Networking Lunch
2:30 pm Scientific Poster Session
First Look at Monovalent Degradation Strategies Taking Aim at High Value Targets
3:30 pm Progress Towards Rational, Structure-Based Design of Next-Generation Glues
Synopsis
For more information on this session, please download the full event guide.
4:00 pm Monofunctional Degradation Activating Compounds: From New Targets to the Clinic
Synopsis
For more information on this session, please download the full event guide.
4:30 pm Gluing the Inflammasome
Synopsis
For more information on this session, please download the full event guide.
5:00 pm Prospective Discovery of Molecular Glue Medicines to Drug High-value Unligandable Targets
Synopsis
For more information on this session, please download the full event guide.
5:30 pm Chair’s Closing Remarks & End of Conference Day Two
