Heterobifunctional Molecules That Induce Targeted Degradation of Extracellular Proteins Through the Cell-Surface Asialoglycoprotein Receptor
Time: 11:00 am
day: Post-Conference Focus Day: Next Generation TPD
Details:
- Clinically validating targeted intracellular protein degradation using the ubiquitin-proteasome system (UPS) motivated us to expand degradation approaches to extracellular proteins using a non-UPS pathway
- Harnessing the natural ASGPR pathway to access the endolysosome of hepatocytes for protein degradation. Heterobifunctional molecules (ASGPR-Targeting Chimeras or ATACs) recruit target proteins of interest through their extracellular domain while interacting with ASGPR for internalization and lysosomal degradation
- Describing the functionality of novel ATAC degraders that leverage Avilar’s proprietary, high-affinity ASGPR-binding ligands
