Development of Novel Therapeutics via Stabilization of 14-3-3: Client Protein Protein Interactions
Time: 3:30 pm
day: Post-Conference Focus Day: Next Generation TPD
Details:
- Regulating the activity of phosphorylated client proteins, many of which are “undruggable”, through 14-3-3, a ubiquitously expressed hub protein
- Binding exclusively to disordered regions of these clients creating an ordered binary complex which can be targeted by small molecule stabilizers
- Developing small molecule therapeutics that bind the composite 14-3-3:client protein surface to drug the undruggable
