Potent & Selective TBK1 Molecular Glue Degraders with Non-Canonical Degron Binding Mode
- Design and screening of our next generation cereblon-focused molecular glue library by highthroughput proteomics that led to the discovery of TBK1 molecular glue degraders
- Optimisation and structural characterisation of MGDs forming non-canonical ternary complex with TBK1 and CRBN
- Pharmacological profiling demonstrating high potency in multiple cancer models in vitro and in vivo