Potent & Selective TBK1 Molecular Glue Degraders with Non-Canonical Degron Binding Mode

• Design and screening of our next generation cereblon-focused molecular glue library by highthroughput proteomics that led to the discovery of TBK1 molecular glue degraders
• Optimisation and structural characterisation of MGDs forming non-canonical ternary complex with TBK1 and CRBN
• Pharmacological profiling demonstrating high potency in multiple cancer models in vitro and in vivo

Speakers:

Zoran Rankovic

Professor of Chemical Biology & Director of the Centre for Protein Degradation

Institute of Cancer Research