Zoran Rankovic
Professor of Chemical Biology & Director of the Centre for Protein Degradation Institute of Cancer Research
Seminars
Wednesday 28th October 2026
Potent & Selective TBK1 Molecular Glue Degraders with Non-Canonical Degron Binding Mode
12:30 pm
- Design and screening of our next generation cereblon-focused molecular glue library by highthroughput proteomics that led to the discovery of TBK1 molecular glue degraders
- Optimisation and structural characterisation of MGDs forming non-canonical ternary complex with TBK1 and CRBN
- Pharmacological profiling demonstrating high potency in multiple cancer models in vitro and in vivo
