Leveraging Neo-native E3 Ligases to Expand Induced Proximity Drug Discovery

• Plexium’s Delta Discovery™ engine has enabled multiple preclinical and clinical programs
• This talk will focus on the identification and optimization of monovalent direct degraders, specific molecular glues that bind a target of interest and recruit an E3 ligase to promote target degradation
• Case studies from BRD4, CRAF, and SMARCA2 will illustrate the application of this approach across Plexium’s drug discovery programs

Speakers:

Kevin Freeman-Cook

Senior Vice President & Head of Chemistry

Plexium Inc.