Leveraging Neo-native E3 Ligases to Expand Induced Proximity Drug Discovery
- Plexium’s Delta Discovery™ engine has enabled multiple preclinical and clinical programs
- This talk will focus on the identification and optimization of monovalent direct degraders, specific molecular glues that bind a target of interest and recruit an E3 ligase to promote target degradation
- Case studies from BRD4, CRAF, and SMARCA2 will illustrate the application of this approach across Plexium’s drug discovery programs