Inducing the Selective Degradation of Cyclin D1 by Interfering with its Folding Pathway
- Application of physics-based computational simulations to map the folding landscape of Cyclin D1 and identify ligandable pockets exposed along its folding pathway
- Discovery and optimization of small molecules that engage a folding intermediate of Cyclin D1, perturb its folding pathway, and induce selective degradation of the nascent protein
- In vitro and in vivo evidence supporting pharmacological targeting of the Cyclin D1 folding pathway as a novel therapeutic strategy