Scaling Proteomics for High-Throughput CRBN Target Discovery
- Scalable proteomics platform transitioning from TMT-based discovery to DIA-enabled high-throughput profiling
- Establishment of a platform to map the CRBN target space, extending neosubstrate recognition beyond the canonical β‑hairpin G‑loop degron
- Discovery of a molecular glue degrader MRT-31619, that drives homo-dimerization of CRBN and promotes its fast, potent, and selective degradation