Debora Bonenfant
Vice President & Head of Proteomics Monte Rosa Therapeutics
Seminars
Thursday 29th October 2026
Scaling Proteomics for High-Throughput CRBN Target Discovery
1:45 pm
- Scalable proteomics platform transitioning from TMT-based discovery to DIA-enabled high-throughput profiling
- Establishment of a platform to map the CRBN target space, extending neosubstrate recognition beyond the canonical β‑hairpin G‑loop degron
- Discovery of a molecular glue degrader MRT-31619, that drives homo-dimerization of CRBN and promotes its fast, potent, and selective degradation
Thursday 29th October 2026
Discussion: Harnessing AI & Computational Modelling to Optimize Design, Specificity & Efficacy of Induced Proximity Molecules to Support the Development of Tolerable, Selective Therapies
10:00 am
- Optimizing PROTAC linkers & E3 ligase pairing with AI and machine learning tools for enhanced selectivity and potency
- Transforming molecular glue design with AI to predict target engagement, enhance selectivity and minimize off-target degradation
- Employing computational tools and modelling approaches to inform therapeutic strategy across induced proximity modalities
Thursday 29th October 2026
Chair’s Opening Remarks
8:20 am
Thursday 29th October 2026
Chair’s Closing Remarks
2:45 pm
