Optimizing Novel Heterobifunctional Degraders – An Update

• Structure-guided discovery and optimization of setidegrasib (ASP3082), a KRAS G12D degrader
• Expanding targeted protein degradation from KRAS G12D to pan-KRAS degraders
• Optimizing degrader-antibody conjugates (DACs) to enhance potency and drug loading

Speakers:

Takashi Sugane

Head, Candidate Delivery, Engineered Small Molecules

Astellas Pharma