Takashi Sugane
Head, Candidate Delivery, Engineered Small Molecules Astellas Pharma
Seminars
Wednesday 28th October 2026
Optimizing Novel Heterobifunctional Degraders – An Update
2:30 pm
- Structure-guided discovery and optimization of setidegrasib (ASP3082), a KRAS G12D degrader
- Expanding targeted protein degradation from KRAS G12D to pan-KRAS degraders
- Optimizing degrader-antibody conjugates (DACs) to enhance potency and drug loading
