Degrader-Antibody Conjugates: Proof of Concept Through Design of a Potent BRD4 Degrading Linker-Payload

• A modular linker strategy was developed to screen BRD4 degrader antibody conjugates (DACs)
• Payload potency correlates well with DAC activity
• Potent DACs to multiple target antigens were identified; however, pre-clinical toxicology limits further development

Speakers:

Joel Courter

Senior Principal Scientist

Pfizer