Degrader-Antibody Conjugates: Proof of Concept Through Design of a Potent BRD4 Degrading Linker-Payload
- A modular linker strategy was developed to screen BRD4 degrader antibody conjugates (DACs)
- Payload potency correlates well with DAC activity
- Potent DACs to multiple target antigens were identified; however, pre-clinical toxicology limits further development