Joel Courter
Senior Principal Scientist Pfizer
Seminars
Thursday 29th October 2026
Degrader-Antibody Conjugates: Proof of Concept Through Design of a Potent BRD4 Degrading Linker-Payload
8:30 am
- A modular linker strategy was developed to screen BRD4 degrader antibody conjugates (DACs)
- Payload potency correlates well with DAC activity
- Potent DACs to multiple target antigens were identified; however, pre-clinical toxicology limits further development
