Kevin Freeman-Cook
SVP chemistry Plexium Inc.
Seminars
Monday 27th October 2025
Application of Plexium’s Picowell Screening Technology to the Identification of Helios Molecular Glue Degraders
10:00 am
- Application of Plexium’s proprietary ultrahigh density Picowell screening technology to the identification of cereblon mediated molecular glue degraders (MGDs) of Helios (IKZF2) will be described
- Hits from the screen were shown to bind to cereblon, and degradation of Helios was independently confirmed in a Helios-GFP assay and by global proteomics. Loss of Helios was rescued by co-treating with a proteasome inhibitor confirming dependence on the ubiquitin proteasome system
- Collectively, these results demonstrate that Plexium’s Picowell screening platform enables the discovery of MGDs of Helios
