Jessica Sims
Senior Principal Scientist Genentech
Seminars
Tuesday 27th October 2026
New Frontiers, New Risks: Mapping the Safety Complexities of Targeted Degradation
12:00 pm
- Evaluation of current methodologies for the identification of neo-substrates (neodegradants) and the subsequent characterization of their toxicological liabilities
- Mechanistic overview of delayed cardiovascular risks associated with targeted protein degraders and the inherent limitations of standard in vitro assays in detecting these liabilities
- Advancements in the development of comprehensive preclinical screening paradigms designed to proactively identify cardiovascular and other class-specific toxicities
