Jason Xiang
Chief Executive Officer & Founder Polymed Biopharmaceuticals
Seminars
Monday 27th October 2025
Workshop C – Optimizing the Right Degrader Properties – Developing Efficient & Dependable TPD Design Principles
2:00 pm
Effective degrader development relies on precise optimization of key molecular properties to ensure robust, reliable degradation efficiency. Explore how to measure these essential properties, build a process for efficient optimization, and develop a platform to create degraders quickly and reliably. Featuring real-world case studies, this session offers practical strategies to streamline degrader design for maximum therapeutic impact. We will cover:
- The creation of HPB-143/VP-776: an optimized IRAK4 PROTAC modeled against the benchmark KT-474
- Identification and development of BCL-XL protein degraders
- Is ternary complex kinetic stability a key driver of degradation efficiency?
Tuesday 28th October 2025
Optimizing EGFR & KRAS G12D Targeting: Polymed’s Integrated Approach to PROTACs & DACs
2:30 pm
