Hong-yu Li
Professor of Pharmacology Health Science Center at San Antonio
Seminars
Monday 27th October 2025
CD36-Mediated Endocytosis of PROTACs
12:00 pm
- Identified CD36 as a membrane target for PROTACs through biotinylated probe-based target fishing
- Demonstrated CD36’s role in facilitating cellular uptake of diverse molecules ranging from 543 to 2,145 Da
- Explored the impact of CD36 knock-down/knock-in on the efficacy of the clinical PROTAC ARV-110 in both in vitro and in vivo models. CD36 knockdown wiped out ARV-110 efficacy in vitro and in vivo
- Leveraged endocytic medicinal chemistry strategies to enhance PROTAC potency and improve drug properties
- Clinical responses of large molecules correlate with the expression of CD36
