Henrik Daub
Chief Scientific Officer NEOsphere Biotechnologies GmbH
Seminars
Tuesday 27th October 2026
High-Throughput Proteomics Powering Molecular Glue Degrader Discovery
12:00 pm
- Large-scale proteomic screening of >5,000 compounds identified and validated 250+ molecular glue degrader targets, among them CDK4
- Mapping chemical structures to degradation and interactomics profiles provides a high-resolution, proteome-wide view of target spectrum, compound-induced protein regulation, and protein-protein interactions
- These datasets fuel proteomics-driven AI/ML, enabling rational molecular glues design and selectivity optimization
