Gisele NIshiguchi
Targeted Protein Degradation Center Leader St. Jude Children's Research Hospital
Seminars
Monday 26th October 2026
Discovery of a Potent & Selective Molecular Glue Degrader of PPIL4 Active in Pediatric Acute Leukemia & Medulloblastoma
11:30 am
- Phenotypic screening of a CRBN based molecular glue library against pediatric cancer cell lines identified a potent cytotoxic compound (SJ42872)
- PPIL4 was identified as a novel neosubstrate using proteomics profiling
- In-vivo studies of SJ42872 in B-ALL and Medulloblastoma cells showed reduced tumor burden and increased survival in mouse models
