Evris Gavathiotis
Professor Albert Einstein College of Medicine
Seminars
Monday 26th October 2026
αC-Helix–Proximal Allostery as a Platform for Selective Kinase Modulation & Complex Degradation
9:30 am
- Introduce a scalable structure-guided platform that combines SuFEx-based high-throughput medicinal chemistry and direct-to-biology screening to systematically discover aC-helix–proximal allosteric pockets across kinases
- Show how aC-helix–proximal engagement yields signaling-state-selective BRAF inhibitors that preferentially target RAF dimers and suppress dimerdependent MAPK signaling
- Demonstrate that the same strategy can generate CDK8/CDK19 modulators that destabilize CDK8/CDK19–Cyclin C complexes and trigger proteasomedependent degradation without requiring bifunctional degrader architectures
Monday 26th October 2026
Panel Discussion: Shaping the Future of Induced Proximity Research to Drive Innovative Discovery & Support the Development of Pipeline-Ready Candidates
2:30 pm
- Outlining recent advancements and breakthroughs defining the induced proximity field
- Creating a pathway for future research and innovation to enable the early development of future clinical candidates
- Highlighting the importance of industry and academia collaboration to enhance patient outcomes
