Effective degrader development relies on precise optimization of key molecular properties to ensure robust, reliable degradation efficiency. Explore how to measure these essential properties, build a process for efficient optimization, and develop a platform to create degraders quickly and reliably. Featuring real-world case studies, this session offers practical strategies to streamline degrader design for maximum therapeutic impact. We will cover:

• The creation of HPB-143/VP-776: an optimized IRAK4 PROTAC modeled against the benchmark KT-474
• Identification and development of BCL-XL protein degraders
• Is ternary complex kinetic stability a key driver of degradation efficiency?