Workshop A – Discovering Ligase-Target Pairings & Kick-Start Molecular Glue Discovery Program & Enable Rational Drug Design

When starting molecular glue development from scratch, finding the right interaction to stabilize is the most crucial

step. In this workshop, you will learn to decode targetligase pairs and accurately visualize ternary complexes to accelerate molecular glue discovery. We will cover:

  • How to identify the right target-ligase pairings with high-throughput assays
  • Choosing the best libraries, assays, and biophysical methods to discover and validate hits for molecular glue development
  • Using in silico modeling to optimize ternary complex visualization