Targeting Extracellular Proteins for Degradation with SORTACs to Enable Tissue-Specific Clearance
- Developing Sortilin-based lysosome-targeting chimeras (SORTACs) to enable selective extracellular protein degradation
- Designing small molecule SORTACs that degrade both soluble and membrane-bound targets with tissue and cell-type specificity
- Demonstrating SORTAC-driven clearance of pathogenic neuronal protein aggregates to open new avenues for neurodegenerative therapies