How NanoTemper Solutions Assist Degrader Workflows, from Initial Screening, Over Optimization to In-Depth Characterization

• Identifying novel Cereblon binders from a high-diversity library using high-throughput screening on Dianthus uHTS
• Investigating the intrinsic cooperativity of a ternary system facilitated by macrocyclic molecular glues using Dianthus α
• Presenting the comprehensive biophysical characterization of the VCB–MZ1–BRD2 complex using Monolith Omni to demonstrate how high throughput screening, affinity measurements, and quantitative ternary-complex analysis can help guide the discovery and optimization of degraders and molecular glues

Speakers:

Jan Schnatwinkel

Product Manager

NanoTemper Technologies