Methylarginine Targeting Chimeras for Lysosomal Degradation of Intracellular Proteins
- Methylarginine degrons are a widespread signal for intracellular protein delivery to lysosomes
- MrTAC is a first-in-class lysosomal degrader
- Methyl-driven lysosomal proteolysis expands the scope of current proximity inducing modalities to new families of undruggable targe