Methylarginine Targeting Chimeras for Lysosomal Degradation of Intracellular Proteins

• Methylarginine degrons are a widespread signal for intracellular protein delivery to lysosomes
• MrTAC is a first-in-class lysosomal degrader
• Methyl-driven lysosomal proteolysis expands the scope of current proximity inducing modalities to new families of undruggable targe

Speakers:

Lauren Albrecht

Assistant Professor

University of California, Irvine