GlueScope: Accelerating Molecular Glue Discovery through Orthogonal Proteomics & Deep Screening

• Building a high-throughput orthogonal proteomics platform integrating proximity, ubiquitination, and degradation profiling
• Expanding the druggable proteome through systematic screening across diverse E3 ligases and disease-relevant cell lineages
• Generating large-scale, AI-ready mechanistic datasets to accelerate molecular glue discovery, prioritization, and mechanism-of-action elucidation

Speakers:

Bo Zhou

Scientific Associate Director, Discovery Proteomics

Amgen Inc.