Expanding the Frontiers of Molecular Glue Discovery: Lessons from the RAS(ON) Tri-Complex Platform
- From concept to compound: How a mechanistically informed screen enabled the discovery of RAS(ON) stabilizing molecular glues
- Assay strategy: Building a platform of biochemical, biophysical, and cell-based assays to evaluate tri-complex formation and function
- Discovery at scale: Lessons learned from integrating covalent and non-covalent screening, and the importance of resolving kinetic and cooperative effects