Expanding Molecular Glue Discovery with a Functional Genomics Platform for Neo-PPI Engineering
- Building a high-throughput, functional genomics-based platform to prospectively induce degradation-conducive neo-protein–protein interactions (neo-PPI)
- Unlocking novel molecular glue degraders by engineering neo-PPI beyond precedented ligase–target pairs
- Showcasing how this approach broadens the degrader discovery landscape with new mechanisms and targets