Diverse Mechanisms of Small Molecule Induced Protein Degradation

• Scalable reporter and screening platforms for systematic analysis of targeted protein degradation
• Defining CRBN substrate recognition rules to expand target discovery and guide rational degrader design
• Mapping mechanisms of degradation induced by small molecules through pooled CRISPR, flow cytometry, and quantitative reporter assays

Speakers:

Mikolaj Slabicki

Affiliate Faculty Member

The Broad Institute of MIT & Harvard