Degrading IRF5, a Highly Validated, Historically Undrugged Transcription Factor
12:45 pm - Wednesday 28th October 2026
- Genetically validated master regulator and amplifier of immune responses in multiple autoimmune diseases
- Human risk variants or functional hyperactivation are associated with increased signaling in multiple clinically validated pathways
- KT-579, a potent, selective, oral IRF5 degrader, preclinical profile in human primary cells, patient derived cells, and in vivo disease models
