Orally Bioavailable NRF2 Molecular Glue Degrader Effective in KEAP1-Mutant Cancer
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- Novel HTS Transcriptomics screen identifies initial NRF2 hit
- Hit and Analog induces an interaction between NRF2 and BTrCP
- Optimized analogs lead to significant in vivo activity in multiple lung cancer models with very favorable drug-like and safety profiles